The relationship between dyslipidemia and chronic liver disease, with the mediating role of depressive symptoms.

ABSTRACT:

Background

Dyslipidemia and chronic liver disease (CLD) remain major global health challenges with high morbidity and mortality rates. Although extensively studied, the association between dyslipidemia and CLD remains incompletely elucidated. Depressive symptoms, an increasingly prevalent comorbidity, have been widely implicated in both conditions. This study aimed to investigate the bidirectional effects between dyslipidemia and CLD and the mediating role of depressive symptoms in their association.

Methods

We recruited 6,926 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS). It used Logistic regression and mediation analysis to examine the bidirectional link between dyslipidemia and CLD, and the mediating role of depressive sympto

SUBMITTER: Li W 

PROVIDER: S-EPMC12414773 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature