Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques.

ABSTRACT:

Introduction

Aging is accompanied by systemic metabolic changes that contribute to disease susceptibility and functional decline. Sex differences in aging have been reported in humans, yet their mechanistic basis remains poorly understood. Due to their physiological similarity to humans, rhesus macaques are a powerful translational model to investigate sex-specific metabolomic aging under controlled conditions.

Methods

Targeted serum metabolomics were conducted in 58 rhesus (35 females, 23 males), ranging from 1.66 to 25.71 years of age, quantifying 513 metabolites spanning lipids, amino acids, and related compounds. Multivariate, univariate, and generalized additive model (GAM) analyses were performed to evaluate age-associated trajectories and test for sex differences.

SUBMITTER: Metzler LAP 

PROVIDER: S-EPMC12414774 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature