Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker.

ABSTRACT:

Purpose

To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker analyses.

Background

The development of blood-based methods for early disease detection has become increasingly desirable across various medical fields. RNA profiles have been investigated but have been a challenge due to rapid degradation of the analyte by ubiquitous RNases. miRNAs are short, non-coding regulatory RNAs that are believed to be more stable under certain conditions, large in number, and specific to cell type and disease state. Thus, circulating miRNA profiles hold significant promise as diagnostic biomarkers for a range of conditions, including cance

SUBMITTER: Katayama ES 

PROVIDER: S-EPMC12414832 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature