Expression of metabolic genes in NK cells is associated with clinical outcomes in patients with severe COVID-19: a brief report.

ABSTRACT: Natural killer (NK) cells are innate lymphocytes with cytotoxic activity against tumors and viruses. The pandemic of the coronavirus disease 2019 (COVID-19) has increased the investigation of their role in disease severity. However, their functional status and modulators remain controversial. Recent studies highlighted the role of metabolism in immune function, but metabolic changes in NK cells during SARS-CoV-2 infection remain unexplored. This study compares metabolic (SIRT1, AMPKA, HIF1A, and GLUT1) and inflammatory (NFKB1, NFKB1A, IFNG, and SOCS1) gene expression, and flow cytometry-based assessment of functional markers in NK cells from severe COVID-19 patients (n=15) and the control group (n=10), and their association with clinical outcomes. Severe COVID-1

SUBMITTER: Osuna-Espinoza KY 

PROVIDER: S-EPMC12415030 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature