Deviance detection and regularity sensitivity in dissociated neuronal cultures.

ABSTRACT:

Introduction

Understanding how neural networks process complex patterns of information is crucial for advancing both neuroscience and artificial intelligence. To investigate fundamental principles of neural computation, we examined whether dissociated neuronal cultures, one of the most primitive living neural networks, exhibit regularity sensitivity beyond mere stimulus-specific adaptation and deviance detection.

Methods

We recorded activity to oddball electrical stimulation paradigms from dissociated rat cortical neurons cultured on high-resolution CMOS microelectrode arrays. We examined the effects of pharmacological manipulation on responses using the N-methyl-D-aspartate (NMDA) receptor antagonist. To assess regularity sensitivity, we compared neural responses between pr

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12415055 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature