Association of the Dietary Index for Gut Microbiota and Cardiovascular-Kidney-Metabolic Syndrome: The Mediation Effect of Phenotypic and Biological Age Acceleration, BMI, and BRI.

ABSTRACT: The relationship between gut microbiota, diet, and cardiovascular-kidney-metabolic (CKM) health has attracted attention. However, the relationship between the dietary index for gut microbiota (DI-GM) and CKM syndrome has not yet been studied. Patients diagnosed with CKM syndrome from the NHANES 2007-2018 data were included. Dietary recall data were used to calculate DI-GM. Restricted cubic splines (RCS) were employed to explore nonlinear relationships and determine the threshold for DI-GM. The relationship between DI-GM and CKM syndrome was analyzed using weighted logistic regression. Further, potential mediating roles of phenotype age acceleration (PAA), biological age acceleration (BAA), body mass index (BMI), and body roundness index (BRI) were explored. Sensitivity analysis using inver

SUBMITTER: Yu D 

PROVIDER: S-EPMC12415064 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature