US-triggered on-demand NO-releasing biomimetic nanoparticle to Remodel endothelial microenvironment for enhancing atherosclerosis-specific gas therapy.

ABSTRACT: Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction, vascular smooth muscle cell proliferation, and insufficient resolution of inflammation. Nitric oxide (NO) plays a crucial role in vascular homeostasis by promoting endothelial cell proliferation, maintaining endothelial integrity, suppressing smooth muscle cell hyperplasia, and exerting potent anti-inflammatory effects. However, clinical application of NO is hindered by its short half-life, lack of targeting, and uncontrolled release. Here, we developed the biomimetic nanoparticles (B-NPs@MM) for targeted and controllable NO delivery by encapsulating the ultrasound (US)-responsive NO donor BNN6 into poly(lactic-co-glycolic acid) (PLGA) nanospheres followed by coating with macrophage-derived membranes.

SUBMITTER: Xu L 

PROVIDER: S-EPMC12415076 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature