Self-enriching nanozyme with photothermal-cascade amplification for tumor microenvironment-responsive synergistic therapy and enhanced photoacoustic imaging.

ABSTRACT: Achieving precise intratumoral accumulation and coordinated activation remains a major challenge in nanomedicine. Photothermal therapy (PTT) provides spatiotemporal control, yet its efficacy is hindered by heterogeneous distribution of PTT agents and limited synergy with other modalities. Here, we develop a dual-activation nanoplatform (IrO_x-P) that integrates exogenous photothermal stimulation with endogenous tumor microenvironment (TME)-responsive catalysis for synergistic chemodynamic therapy (CDT) and ferroptosis induction. The IrO_x core exhibits robust peroxidase- and catalase-like activities, enabling Ir³⁺/Ir⁴⁺ redox cycling for glutathione depletion, hydroxyl radical generation and O₂ production. Surface conjugation of P-selecti

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12415079 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature