Magnetic decoupling as a proofreading strategy for high-yield, time-efficient microscale self-assembly.

ABSTRACT: Life thrives due to its remarkable ability to create complex structures through the self-assembly of proteins, nucleic acids, and other biomolecules. Achieving such complex assemblies with the same level of fidelity, reproducibility, and advanced functionality in synthetic systems, however, has remained a grand challenge. One outstanding problem is the presence of parasitic products and long-lived intermediate states that slow the reaction process and limit the yield of the final product. Biology overcomes this challenge by proofreading to recognize and disassemble parasitic products. Such local checks, however, are currently difficult to implement in available self-assembly platforms. Here, we overcome this challenge by implementing a proofreading mechanism in a self-assembly platform. Sp

SUBMITTER: Liang Z 

PROVIDER: S-EPMC12415251 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature