Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice.

ABSTRACT: The Foxp3⁺CD4⁺ regulatory T cells (Tregs) generated around birth are phenotypically and functionally distinct from those engendered during adulthood. That perinatally produced Tregs persist for a protracted period in peripheral lymphoid organs has been well documented, as has their superior ability to protect the organism from many autoimmune diseases. However, their contribution to pools of nonlymphoid-tissue Tregs and their homeostatic functions therein have been little studied. We show that perinatal Tregs preferentially derive from a CD25⁺Foxp3^- thymocyte progenitor; that they seed and persist to varying degrees in every nonlymphoid tissue examined; and that transient depletion of perinatally generated Tregs in adults, but not in neonates, is

SUBMITTER: Marin-Rodero M 

PROVIDER: S-EPMC12415289 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature