What spatial omics is teaching us about field cancerisation in prostate and bladder cancer.

ABSTRACT:

Background and objectives

Field cancerisation is the process that results in a group of cells acquiring some of the phenotypic changes of cancer prior to transformation into cancer. Clinically, an important challenge remains the ability to distinguish clonal lineages and microenvironments within cancerised fields that will remain indolent from those that will progress to malignant transformation. Spatial 'omics' can help us investigate genetic, epigenetic, transcriptomic, proteomic, and cellular microenvironments that transform normal cells into a cancerised field, and subsequently into cancer. In this review, we will discuss how spatial omics techniques have expanded our understanding of field cancerisation in prostate and bladder cancer, and the challenges associated with this re

SUBMITTER: Byrne MHV 

PROVIDER: S-EPMC12415322 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature