Immediate and durable effects of maternal tobacco consumption on placental DNA methylation: a replication and discovery study.

ABSTRACT: An increasing number of epigenome-wide association studies report tobacco smoking-associated DNA methylation levels. However, comprehensive replication studies remain scarce, particularly in placenta, despite their crucial interest in such a large-scale context. Using DNA methylation data from the EPIC array of 341 new placentas (85 smokers, 219 non-smokers, and 37 former smokers) from the EDEN cohort, we used a candidate approach to replicate maternal smoking-associated CpGs and regions previously identified using the 450K array, and an exploratory approach to discover new associations within EPIC-specific CpGs. Smoking-associated changes in DNA methylation in CpGs and regions were classified as either transient or persistent (indicating epigenetic memory), depending on the stability of t

SUBMITTER: Masdoumier C 

PROVIDER: S-EPMC12415551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature