Global maintenance of histone post-translational modifications during the transition into anoxia in embryos of the annual killifish <i>Austrofundulus limnaeus</i>.

ABSTRACT: Many organisms have adapted to survive anoxic or hypoxic environments, but the epigenetic responses involved in this successful stress response are not well described in most species. Embryos of the annual killifish Austrofundulus limnaeus have the greatest tolerance to anoxia of all vertebrates, making them a powerful model to study the cellular mechanisms necessary for anoxia tolerance. However, the global histone landscape of this species has never been quantified or explored in relation to stress tolerance. Liquid chromatography-mass spectrometry and a Python bioinformatics workflow were used to identify histones and their post-translational modifications. This pipeline resulted in the detection of 252 unique biologically relevant histone post-translational modifications (hPTMs)

SUBMITTER: Hughes C 

PROVIDER: S-EPMC12415556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature