Comparative Effectiveness of Opioids and Opioid Substitutes on Pain and Health Related Quality of Life Among Cancer Survivors.

ABSTRACT:

Introduction

Chronic pain is a major but modifiable contributor to poor quality of life among long-term cancer survivors. With growing concern over opioid-related risks, gabapentinoids have emerged as a safer alternative, though evidence comparing their effectiveness remains limited.

Methods

We conducted a retrospective cohort study using SEER-MHOS linked data (1998-2021) to examine pain interference and health-related quality of life (HRQoL) among 24,651 cancer survivors. Participants were categorized as opioid-only (OPIOID-only), gabapentinoid-only (GABA-only), both (BOTH), or no medication (NONE). Changes in pain interference and Physical and Mental Component Summary scores (PCS, MCS) were analyzed using paired t-tests and multivariate regression, adjusting for demographi

SUBMITTER: Chan Sanchez SK 

PROVIDER: S-EPMC12415586 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature