Racial differences in serum chemokines in prostate cancer patients.

ABSTRACT:

Background

This study aimed to understand the differential levels of inflammatory chemokines in association with higher prostate cancer incidence and mortality in African American (AA) men than in Caucasians (CA).

Methods

The authors used a chemokine assay to simultaneously measure 40 chemokines and cytokines levels in the serum of preoperative prostate cancer patients and healthy controls of AA and CA races. Selected chemokines (CXCL2, CXCL5, and CCL23) serum level was validated in 211 serum samples from prostate cancer patients and healthy controls. Differential expression of CXCL5 and CCL23 was analyzed using immunohistochemistry in a representative cohort of prostate tumor tissues of AA and CA races.

Results

Race-specific comparisons from 211 serum samples showed

SUBMITTER: Karan D 

PROVIDER: S-EPMC12415822 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature