Identifying Poor Responders to STN DBS in Parkinson Disease: The Role of Rapid Disease Progression in the First Year in Optimal Responders to Levodopa.

ABSTRACT:

Background

The factors contributing to a poor response to subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not yet fully understood. Accordingly, predicting the outcome might be challenging particularly in those who display an optimal response to the Levodopa challenge test.

Objective

To determine which factors may contribute to poor outcome of STN-DBS in PD.

Methods

We performed a retrospective analysis of consecutive PD patients treated with STN-DBS. Motor and non-motor variables were retrieved before surgery and at 1-year follow-up. Patients were divided into poor and good DBS responders by a cut-off value of less than 20% improvement of UPDRS-II in the OFF-medication ON-stimulation condition at 1 year.

Results

Thirty-two

SUBMITTER: Morgante F 

PROVIDER: S-EPMC12415869 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature