MiRNA-494 in Lymphocytes: A Promising Biomarker for Acute Ischemic Stroke.

ABSTRACT:

Background

microRNA-494 (miRNA-494) plays a key role in neuroinflammation following cerebral ischemia. We aimed to assess miRNA-494 levels as a biomarker for predicting acute ischemic stroke (AIS) severity and outcomes.

Methods

miRNA-494 levels in peripheral lymphocytes were measured using reverse transcription-quantitative polymerase chain reaction. Least Absolute Shrinkage and Selection Operator (LASSO) regression was employed to identify variables for multivariate logistic regression analysis. Univariate and multivariate logistic regression were conducted to assess the association between miRNA-494 levels and both AIS outcomes and stroke severity on admission. The primary outcome was defined as an excellent prognosis (modified Rankin Scale score of 0 or 1). The secondary

SUBMITTER: Xie Z 

PROVIDER: S-EPMC12415885 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature