Penicillin and Gentamicin Concentrations in the Uterine Fluid of Non-Pregnant Mares Following a Single Intrauterine Infusion.

ABSTRACT: Despite their widespread clinical use, there is limited pharmacokinetic data for many equine intrauterine antimicrobials. This study aimed to measure the concentration of gentamicin and penicillin in the uterine fluid of mares following infusion of either a standard (PPGent) or long-acting (LA-PPGent) compounded formulation. We hypothesized that both formulations would result in therapeutic concentrations, with total concentrations sustained for longer using the long-acting formulation. Mares were administered 2400 mg of procaine penicillin and 200 mg of gentamicin via a single intrauterine infusion in either a standard (n = 6) or a lyophilized formulation suspended in a slow-release matrix (n = 6). Intrauterine fluid was collected over a 72-h period and analyzed for antibiotic concentrati

SUBMITTER: Bailey CS 

PROVIDER: S-EPMC12415939 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature