Electrochemical Copper Catalysis: A Triple Catalytic System for Transient C(sp²)-H Functionalization through Mediated Electrolysis.

ABSTRACT: The development of copper-catalyzed C-H functionalization processes is challenging due to the inefficiency of conventional chemical oxidants in regenerating the copper catalyst. This study details the development of a mediated electrosynthetic approach involving triple catalytic cycles in transient C-H functionalization to achieve efficient copper-catalyzed C-(sp²)-H sulfonylation of benzylamines with sodium sulfinate salts. The triple catalytic system consists of a copper organometallic cycle for C-H functionalization, an aldehyde transient directing group (TDG) as an organocatalyst for imine formation, and a ferrocenium salt as an electrocatalyst. This mediated electrolysis strategy addresses key challenges associated with copper electrochemical C-H activation, including irrev

SUBMITTER: Ma TK 

PROVIDER: S-EPMC12415948 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature