Identification of GABBR2 as a diagnostic marker and its association with Aβ in Alzheimer's disease.

ABSTRACT:

Background

Synaptic dysfunction and synapse loss occur in Alzheimer's disease (AD). The current study aimed to identify synaptic-related genes with diagnostic potential for AD.

Methods

Differentially expressed genes (DEGs) were overlapped with phenotype-associated module selected through weighted gene co-expression network analysis (WGCNA), and synaptic-related genes. The overlapped hub genes were further processed using machine learning algorithms, intersected with module gene from protein-protein interaction (PPI) network constructed with DEGs, to yield co-hub genes. The diagnostic potentials of the co-hub genes were examined by receiver operating characteristic (ROC) analysis. Correlation between co-hub genes with clinical features and immune cell infiltration was analyze

SUBMITTER: Li H 

PROVIDER: S-EPMC12415974 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature