Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants.

ABSTRACT:

Background

Frontotemporal dementia (FTD) encompasses diverse clinical phenotypes, primarily characterized by behavioral and/or language dysfunction. A newly characterized variant, semantic behavioral variant FTD (sbvFTD), exhibits predominant right temporal atrophy with features bridging behavioral variant FTD (bvFTD) and semantic variant primary progressive aphasia (svPPA). This study investigates the longitudinal structural MRI correlates of these FTD variants, focusing on cortical and subcortical structural damage to aid differential diagnosis and prognosis.

Methods

Seventy-one FTD patients (bvFTD = 45, sbvFTD = 11, svPPA = 15) and 37 healthy controls participated in a prospective study involving up to 24 months of serial neurological, neuropsychological, and 3 T MRI asse

SUBMITTER: Spinelli EG 

PROVIDER: S-EPMC12415986 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature