Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus.

ABSTRACT: Estrogen has profound effects on the brain, affecting neuronal plasticity and behavior. Perineuronal nets (PNNs) are perforated extracellular matrix structures that mostly surround parvalbumin (PV)-expressing inhibitory interneurons and regulate neuronal activity, synaptic plasticity and behavior. PNNs have sex-specific effects on behavior, suggesting that hormones like estrogen may be involved in these sex differences. In this study, we investigated the effects of estrous cycle and estrogen on PNNs in the hippocampus and insular cortex of female mice. PNNs and PV protein were detected by fluorescence labeling with the plant lectin WFA and PV immunostaining, respectively, throughout the estrous cycle, following treatment with estradiol, and after chronic administration of the aromatase inh

SUBMITTER: Nguyen R 

PROVIDER: S-EPMC12415989 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature