Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study.

ABSTRACT:

Background

The progressive legalization and widespread use of cannabis has led to its use as a treatment for certain neuropsychiatric disorders. Traditional epidemiological studies suggest that cannabis use has an effect on some neurocognitive aspects. However, it is unclear whether cannabis use is causally related to common neuropsychiatric disorders. The present study was conducted to illustrate the causal relationships of genetically predicted cannabis use with common neuropsychiatric disorders.

Methods

We used a two-sample Mendelian randomization method using genome-wide association study (GWAS) summary statistics obtained from publicly available databases on lifetime cannabis use and 10 neuropsychiatric disorders, including multiple sclerosis (MS), Alzheimer's disease (

SUBMITTER: Guo W 

PROVIDER: S-EPMC12416058 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature