Diet-microbiome synergy: unraveling the combined impact on frailty through interactions and mediation.

ABSTRACT:

Objective

This study analyzed data from the US population to examine how oral microbiome diversity and diet quality individually and synergistically affect frailty.

Methods

This study included 6,283 participants aged 20 years or older from the 2009-2010 and 2011-2012 NHANES cycles. A frailty index (FI) consisting of 36 items was developed, with items related to nutritional status excluded. The diversity of the oral microbiome was assessed using α-diversity, including observed ASVs, the Shannon-Weiner index, Faith's phylogenetic diversity (PD), and the Simpson index. Dietary quality was assessed using Dietary Inflammatory Index (DII), Dietary Approaches to Stop Hypertension (DASH), Mediterranean Diet Score (MED), and Alternate Healthy Eating Index (AHEI). Multivariable logist

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12416071 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature