Intranasal zinc and vitamin A treatments alter response to bovine respiratory syncytial virus and <i>Mannheimia haemolytica</i> co-infection.

ABSTRACT: During disease, there may be increased local demands for zinc (Zn) and vitamin A to support pathogen response. This study evaluates the effects of intranasal Zn and vitamin A treatments on steers experimentally infected with bovine respiratory disease (BRD) pathogens, bovine respiratory syncytial virus (BRSV) and Mannheimia haemolytica, hypothesizing that steers treated with Zn and vitamin A (VA) will have improved recovery to BRD challenge. Forty-eight Angus crossbred steers (333 ± 4.2 kg) were utilized in two groups with identical challenge timelines. The day prior to challenge (d -1), steers were shipped for 6 hours. On d 0, steers were administered an aerosol inoculation with ~10⁴ TCID₅₀/mL BRSV strain 375 followed by an intratracheal inoculation with M.

SUBMITTER: Rients EL 

PROVIDER: S-EPMC12416139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature