Correlation between the immune response to COVID-19 vaccines and the constitutions of traditional Chinese medicine.

ABSTRACT: Traditional Chinese Medicine (TCM) classifies individuals into constitution types that may influence physiological responses. SARS-CoV-2 vaccines induce spike-specific antibodies and activate B and T cells, including memory subsets. This study investigates whether TCM constitution types are associated with immune responses and adverse events following COVID-19 vaccination. From March 2021 to December 2023, 78 adults received two doses of the COVID-19 vaccine, including AstraZeneca, Moderna, MVC-COV1901, and Pfizer-BioNTech. PBMCs were collected before and after vaccination. Immune parameters-cytokines, antibody titers, dendritic cells (DCs), T cells, B cells, and memory T cell subsets-were measured. TCM constitution scores were determined using the Constitution in Chinese Medicine Question

SUBMITTER: Chen P 

PROVIDER: S-EPMC12416171 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature