Genetic insights into the interaction between chronic hepatitis B virus infection and metabolic syndrome.

ABSTRACT: The association between chronic hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains controversial. We aimed to analyze the causal effects of chronic HBV infection on MetS components and vice versa. Mendelian randomization (MR) was applied to explore the genetic association of chronic HBV infection with both metabolic risk factors and metabolic diseases using summary-level data from GWAS. Further colocalization and mediation analyses were performed for traits with significant causal relationships. The effect of HBV on lipid metabolism was validated by in vitro assays. In European populations, the MR analyses did not support causal relationships between chronic HBV infection and metabolic traits. In East Asian populations, chronic HBV infection was associated with

SUBMITTER: Zou J 

PROVIDER: S-EPMC12416189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature