Electro-impedimetric detection of human anti-mycolate antibody biomarkers of TB before, during, and after treatment.

ABSTRACT:

Aim

This study assessed electro-impedimetric detection (EIS-MARTI) of anti-mycolate antibodies (AMAb) in TB patients before, during, and after treatment, compared to sputum culture (MGIT) as the gold standard.

Methods

A prospective pilot study enrolled 15 confirmed TB patients and 73 healthy controls at a Pretoria hospital (2016-2017). A prospective monitoring study followed 25 confirmed TB patients over 6 months of treatment at a Pretoria clinic (2019-2020) to evaluate biomarker behavior. Outcomes were analyzed using descriptive statistics, wherein diagnostic accuracy and predictive values were assessed by ROC curve analysis.

Results

EIS-MARTI detected 14/15 true TB-positive cases independent of HIV co-infection and 68/73 true TB-negatives in the pilot study. In the

SUBMITTER: Baumeister C 

PROVIDER: S-EPMC12416203 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature