Eikonal Phase Retrieval: unleashing the potential of fourth-generation sources for enhanced propagation-based tomography on biological samples.

ABSTRACT: The evolution of synchrotrons towards higher brilliance beams has increased the possible sample-to-detector propagation distances for which the source confusion circle does not lead to geometrical blurring. This makes it possible to push near-field propagation-driven phase-contrast enhancement to the limit, revealing low-contrast features that would otherwise remain hidden under excessive noise. Until now, this possibility was hindered in many objects of scientific interest by the simultaneous presence of strong phase gradient regions and low contrast features. The strong gradients, when enhanced with the now possible long propagation distances, induce such strong phase effects that the linearization assumptions of current state-of-the-art single-distance phase retrieval filters are broken

SUBMITTER: Mirone A 

PROVIDER: S-EPMC12416417 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature