Water-Soluble Molecular Wires for Membrane Potential Imaging.

ABSTRACT: Voltage-sensitive probes based on donor-acceptor dyads, whose fluorescence is modulated by photoinduced electron transfer (PET) in response to changes in membrane potential, are known as PET molecular wires. PET wires have been widely used in cultured cells; however, their applications in tissue-level imaging have been hampered by their inadequate aqueous solubility, necessitating pre-dissolution in organic solvents that potentially can cause toxic effects. Here we present the synthesis, electronic structure analysis, photophysical characterization, and initial demonstration of water-soluble amphiphilic molecular wires, consisting of a rosamine, as a fluorescent PET acceptor, and a PET donor consisting of a conjugated bridge terminated by dimethylaniline (DMA). The rosamine moiety is exten

SUBMITTER: El Khatib M 

PROVIDER: S-EPMC12416456 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature