Bioelectrosynthesis of Signaling Molecules for Selective Modulation of Cell Signaling.

ABSTRACT: Bioelectrosynthesis holds great potential for studying and regulating biological systems through the in situ synthesis and delivery of cell signaling molecules with high spatiotemporal precision. Despite recent advancements, precise control over multiple signaling molecules within a single platform remains challenging. Here, we introduce a bioelectrosynthesis approach capable of selectively producing two types of signaling molecules from a single precursor. This system leverages multi-metal sulfide electrocatalysts inspired by denitrifying enzymes, which generate signaling molecules, nitric oxide (NO), and ammonia (NH₃) from nitrite ions. By controlling catalytic active sites, NO or NH₃ can be selectively produced under mild electric fields in physiologically relevant

SUBMITTER: Lee M 

PROVIDER: S-EPMC12416457 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature