A Bambusuril Receptor Binds Charge Diffuse Anions in Water at Picomolar Concentrations.

ABSTRACT: Anionic pollutants are widespread in the environment and pose risks to human health. Due to the typically low concentrations of these species, the development of efficient receptors for their detection and removal from aqueous solutions is highly desirable. Here, we report the design and synthesis of a bambusuril receptor with markedly enhanced anion-binding affinity in water, achieved by introducing trifluoromethyl electron-withdrawing groups. The resulting fluorinated receptor is, to date, the most potent known receptor for several charge diffuse anions in aqueous media. The most stable 1:1 host-guest complex in water was observed with iodide, exhibiting a relative dissociation constant of 59 pM. This complex is over three orders of magnitude more stable than any previously reported comp

SUBMITTER: Grewal S 

PROVIDER: S-EPMC12416460 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature