Platinum-Catalysed Hydrofluorination of Alkynes at Room Temperature Promoted by a Fluoride Shuttle.

ABSTRACT: Hydrofluorination of alkynes provides a synthetic route to access fluoroalkenes, a class of compounds with wide applications in chemical research. Herewith, we describe an exceptional hydrofluorination process of alkynes catalysed by Pt(II) complexes at room temperature. Various Pt(II) dichloride complexes bearing chelating phosphines were synthesised and studied towards their catalytic behaviour. Mechanistic investigations suggest the involvement of a dicationic Pt(II) bis(alkyne) species as well as a cationic ß-fluorovinyl Pt(II) complex in the catalytic cycle. Remarkably, the hydrofluorination is enabled by fluorinated anions. The corresponding acids BF₃, HF as well as PF₅ act as fluoride shuttles to allow for an outer-sphere fluorination of the metal-bound substra

SUBMITTER: He O 

PROVIDER: S-EPMC12416478 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature