Modern Concept of Depression Pathogenesis: The Contribution of I.P. Lapin's Research Team.

ABSTRACT:

Background

The advent of neuroleptics and antidepressant therapy marked a significant step forward in clinical psychiatry. Numerous experiments worldwide had been dedicated to a search for the potential neurobiological mechanisms underlying the potency of new psychopharmacological drugs. The first laboratory of psychopharmacology in the USSR was established in 1960 at the Leningrad Psychoneurological Institute. It was headed by Professor Izyaslav Petrovich Lapin. The foundational article by Lapin I.P. and Oksenkrug G.F. (The Lancet, 1969) continues to be cited 55 years after its publication, which determines the interest in the role of this research team in shaping temporal concepts of the pathogenesis of depression and the development of psychopharmacology.

Aim

To analyze t

SUBMITTER: Neznanov N 

PROVIDER: S-EPMC12416560 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature