Drug-induced vitiligo: a real-world pharmacovigilance analysis of the FAERS database.

ABSTRACT:

Background

In recent years, with the expanding use of novel therapeutics such as immune checkpoint inhibitors and monoclonal antibodies, reports of drug-induced vitiligo have been increasing. This study aimed to identify drugs associated with vitiligo using the FDA Adverse Event Reporting System (FAERS).

Methods

A retrospective disproportionality analysis was performed on FAERS reports from the first quarter of 2004 to the fourth quarter of 2024. Disproportionality signals were assessed using the Reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN).

Results

The present study identified 1,910 cases of vitiligo, with a median age of 54 years (interquartile range [IQR]: 40.0-66.0). The gender distribution among these cases was 45.9% femal

SUBMITTER: Shen N 

PROVIDER: S-EPMC12416669 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature