Causal associations between psoriasis and atopic dermatitis: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Although previous studies suggested associations between psoriasis and atopic dermatitis (AD), the directionality and causality of these relationships remain controversial. This study employed bidirectional Mendelian randomization to investigate the potential causal relationships between these two inflammatory skin conditions.

Methods

Genome-wide association statistics were obtained for psoriasis and AD from large-scale consortia and meta-analyses of genome-wide association studies. Inverse-variance weighting, as the primary analysis, was combined with five complementary sensitivity analyses to evaluate the robustness and potential pleiotropy of the data. Additionally, we performed gene mapping of psoriasis-associated single-nucleotide polymorphisms and subsequent

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12416699 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature