Circulating metabolites in patients with chronic heart failure are not related to gut leakage or gut dysbiosis.

ABSTRACT:

Background

The gut microbiota produces numerous metabolites that can enter the circulation and exert effects outside the gut. Several studies have reported altered gut microbiota composition and circulating metabolites in patients with chronic heart failure (HF) compared to healthy controls. Limited data is available on the interplay between dysbiotic features of the gut microbiota and altered circulating metabolites in HF patients. We aimed to examine differences in circulating metabolites between people with and without chronic HF, and their association with gut microbiota dysbiosis and cardiac function.

Methods

We collected plasma, serum, and stool samples from 123 adult patients with stable chronic HF and left ventricular ejection fraction (LVEF) ≤40%, and healthy contro

SUBMITTER: Nendl A 

PROVIDER: S-EPMC12416712 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature