Pinoresinol enhances oral barrier integrity and function in human buccal cell monolayers.

ABSTRACT: The oral epithelial barrier plays a crucial role in maintaining oral health by protecting against microbial invasion and mechanical stress while regulating selective permeability. Disruption of this barrier contributes to inflammation and the development of oral diseases such as gingivitis and periodontitis. Pinoresinol, a lignan with antioxidant, antimicrobial, and anti-inflammatory properties, has demonstrated health benefits in systemic diseases; however, its effects on oral epithelial barrier integrity remain unclear. This study investigated the potential of pinoresinol to enhance oral epithelial barrier function using TR146 cell monolayers. Pinoresinol treatment significantly reduced apparent permeability and increased transepithelial electrical resistance, indicating improved barrier

SUBMITTER: Shin SB 

PROVIDER: S-EPMC12416738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature