Associations of Synaptosome-associated Protein 25 Gene Polymorphism, Autonomic Nervous System Activity, and Recovery of Consciousness from Propofol Anesthesia.

ABSTRACT:

Background

The release of synaptic neurotransmitters and function of presynaptic proteins are essential for maintaining nervous system excitation. General anesthesia is a reversible state characterized by the loss of consciousness and reduced responsiveness. This study hypothesized that polymorphisms in one or more genes encoding the three presynaptic proteins composing the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complex affect consciousness and autonomic nerve function during propofol anesthesia.

Method

One hundred thirty preoperative patients volunteered to undergo a simulated anesthesia procedure. The participants were genotyped for candidate single-nucleotide polymorphisms using the Sanger method. Changes in verbal commands, eyelash

SUBMITTER: Ma G 

PROVIDER: S-EPMC12416901 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature