Application of metagenomics sequencing to diagnose paralytic rabies with stroke-like onset: a case report.

ABSTRACT:

Background

Rabies is an acute zoonotic infectious disease caused by infection with a virus of the genus Lyssavirus. We report a case of paralytic rabies with a stroke-like onset, which was diagnosed using metagenomics next-generation sequencing (mNGS).

Case presentation

A 58-year-old man was admitted to the hospital with "numbness and weakness in the right upper extremity for 2 days, aggravated for 1 day." Twenty-five days before his admission, the patient was bitten on the back of right hand by an unvaccinated domestic dog, resulting in a penetrating injury, classified as grade III according to the rabies exposure classification method. Following admission, the patient exhibited rapidly progressive stroke symptoms, and on the second day, he suffered a sudden respiratory arr

SUBMITTER: Lin B 

PROVIDER: S-EPMC12417114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature