Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.

ABSTRACT:

Background

This study aimed to compare clinical outcomes in NMOSD patients with non-AQP4-IgG autoantibodies, specifically anti-connective tissue disease antibodies (anti-CTD Abs) and antithyroid antibodies (ATAbs), to evaluate their impact on disease severity and prognosis.

Methods

A retrospective analysis was conducted using data from NMOSD inpatients with follow-up periods ≥180 days, stratified by antibody status: anti-CTD Abs (+)/(-), ATAbs (+)/(-), or double positivity (+)/(-). The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.

Results

(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) leve

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12417128 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature