Inflammatory changes in early dementia with Lewy bodies.

ABSTRACT:

Objective

To examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB).

Background

Evidence for inflammation in synucleinopathies has been building. An extensive number of studies have documented inflammatory changes in Parkinson's disease (PD), but much less is known about DLB. Post-mortem DLB brains show T-cell infiltration, and flow cytometry and cytokine/chemokine measures in DLB subjects have suggested the presence of inflammatory responses in DLB. However, there is limited understanding if immune cell changes are present at the earliest stages of DLB.

Methods

We recruited a small, exploratory cohort of nine subjects with Mild Cognitive Impairment-Lewy Bodies (MCI-LB) as part of the broader Alabama Udall cohort study, which is

SUBMITTER: Yacoubian TA 

PROVIDER: S-EPMC12417133 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature