Comparative proteomics of <i>Listeria monocytogenes</i> strains of food and clinical origin reveals strain-specific adaptation mechanisms.

ABSTRACT: Listeria monocytogenes is a foodborne pathogen capable of surviving in diverse environments, including food-processing settings and the human host. This study compared the proteomic profiles of two Listeria monocytogenes strains grown at 37 °C to simulate host-associated conditions: a hypovirulent, food-derived strain and a hypervirulent strain isolated from a human clinical sample. This approach enabled the identification of temperature-induced changes in virulence factors, providing valuable insights into molecular determinants of pathogenicity and potential intervention strategies. Mass spectrometry identified 954 proteins, 642 of which were predicted to be immunogenic. Among these, 128 were unique to the food-derived strain (F), and 29 were specific to the clinical strain

SUBMITTER: Krasteva I 

PROVIDER: S-EPMC12417150 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature