Potential protective regulatory effects on radiation-induced esophageal injury in TUT4^-/- mice.

ABSTRACT:

Introduction

Terminal uridyl transferase 4 (TUT4), a nucleotide transferase that modifies miRNA sequences, plays a critical role in regulating miRNA target interactions and function. However, its involvement in radiation-induced esophageal injury remains poorly understood.

Methods

To investigate this, we performed computational analysis of RNA-seq data from irradiated esophageal tissues of wild-type and TUT4-knockout (TUT4^-/-) mice, identifying 53 differentially expressed mRNAs (DEmRNAs), of which 30 were upregulated and 23 downregulated.

Results

Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DEmRNAs were significantly associated with biological processes including lipid metabolism, fatty acid metabolism, p

SUBMITTER: Ren H 

PROVIDER: S-EPMC12417170 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature