Optimized <i>Ginkgo biloba</i> extract EGb 761^®: boosted therapeutic benefits with minimized CYP enzyme interference.

ABSTRACT:

Object

The development of cognitive-enhancing drugs from Ginkgo biloba extract is actively pursued worldwide. This study compares the chemical compositions of different G. biloba extracts and their formulated drugs, highlighting the distinguishing characteristics and potential benefits of optimized G. biloba extract, EGb 761^®.

Methods

We analyzed three G. biloba extracts and fifteen formulated drugs using HPLC, principal component analysis, and LC-MS/MS to identify key compositional differences. Molecular docking analysis was conducted to evaluate the binding affinity of the key component with a target protein involved in cognitive enhancement. CYP inhibition assays were performed on selected extracts and their derived products to exami

SUBMITTER: Kwon S 

PROVIDER: S-EPMC12417213 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature