Intravenous thrombolysis before endovascular therapy for acute ischemic stroke due to tandem lesions: a systematic review and meta-analysis.

ABSTRACT: The role of intravenous thrombolysis (IVT) in patients with tandem lesions (TL) undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) remains a subject of ongoing debate. The substantial clot burden and the potential need for periprocedural antiplatelet therapy during emergent carotid stenting (CAS) add to the complexity of treatment decisions. This study aims to systematically review and meta-analyze the literature to evaluate the comparative safety and efficacy of IVT plus EVT versus EVT alone in AIS patients with TL. A systematic search was conducted across four databases to identify studies comparing outcomes for patients with TL receiving IVT prior to EVT with those receiving EVT alone. Outcomes of interest included symptomatic intracranial hemorrhage (sICH), func

SUBMITTER: Rodriguez-Calienes A 

PROVIDER: S-EPMC12417230 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature