Quantitative MRI detects delayed perfusion and impact of bronchial artery dilatation on pulmonary circulation in patients with cystic fibrosis.

ABSTRACT:

Objectives

MRI detects abnormal lung perfusion in patients with cystic fibrosis (CF). However, little is known about the contribution of bronchial arteries to lung perfusion in CF. We hypothesized that delayed perfusion can be detected by dynamic contrast-enhanced (DCE-)MRI and that bronchial artery dilatation (BAD) is associated with changes in lung perfusion.

Materials and methods

Morpho-functional MRI was prospectively acquired in 75 patients with CF (18.7 ± 7.6 years, range 6-39 years). Lungs and perfusion defects were segmented automatically to quantify perfusion defects in percent (QDP). Pulmonary blood flow (PBF), mean transit time (MTT), and perfusion delay were calculated for the whole lung, inside normally perfused and perfusion defect areas. Chest MRI score and BA

SUBMITTER: Leutz-Schmidt P 

PROVIDER: S-EPMC12417259 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature