Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study.

ABSTRACT:

Background and purpose

Efgartigimod has demonstrated efficacy in generalized myasthenia gravis (gMG) in both clinical trials and real-world studies. However, factors influencing early response have been less reported. This study aimed to evaluate the efficacy of efgartigimod in a multicenter gMG cohort and to identify the clinical factors associated with early therapeutic response.

Methods

This multicenter, real-world, retrospective, observational study included 115 gMG patients administered efgartigimod across four myasthenia gravis (MG) centers. Responders were defined as patients with a ≥ 2-point Myasthenia Gravis Activities of Daily Living (MG-ADL) or ≥ 3-point Quantitative Myasthenia Gravis Score (QMG) score reduction, while early responders were those achieving score r

SUBMITTER: Zhu W 

PROVIDER: S-EPMC12417274 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature