Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy.

ABSTRACT:

Objective

To characterize MRI changes of brain metastases (BM) following laser interstitial thermal therapy (LITT), particularly in lesions exhibiting durable response or early progression.

Materials and methods

Longitudinal scans from patients with LITT-treated BM were retrospectively analyzed. Treatment response was categorized as durable response, long-term disease control (i.e., stable at 1 year), stable disease < 1 year, or progression < 1 year. Volumetric and diffusion MRI changes after LITT were analyzed for each subregion (contrast-enhancing, central non-enhancing, whole lesion). Volumetric changes were modeled with bi-exponential fits in responding lesions and progressors.

Results

295 MRI scans from 47 lesions across 42 patients (57.8 ± 14.3 years old, males:

SUBMITTER: Sanvito F 

PROVIDER: S-EPMC12417287 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature