Hypertension in pregnancy and in midlife and the risk of dementia: prospective study of 1.3 million UK women.

ABSTRACT:

Introduction

Midlife hypertension is associated with dementia risk, although uncertainties remain regarding its association with subtypes and regarding the effect of pregnancy-related hypertension on dementia risk.

Methods

In the Million Women Study, 1,363,457 women (mean age 57) were asked about current treatment for hypertension and hypertension in pregnancy and were followed for first hospital record with any mention of dementia. Cox regression yielded hazard ratios (HRs) adjusted for socioeconomic, lifestyle, and metabolic factors.

Results

With 84,729 dementia cases over 21 years, midlife hypertension was positively associated with dementia (HR 1.17, 95% confidence interval [CI] 1.15 to 1.19); higher for vascular dementia (VaD) (HR 1.50; 95% CI 1.45 to 1.56) than

SUBMITTER: Floud S 

PROVIDER: S-EPMC12417322 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature